Interleukin-17A derived from mast cells contributes to fibrosis in gastric cancer with peritoneal dissemination.

Katsuya GunjigakeJun KinoshitaTakahisa YamaguchiHiroto SaitoDaisuke FujimoriToshihide HoriikeShinichi HaradaHidehiro TajimaItasu NinomiyaTetsuo OhtaSachio Fushida

Published in: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association (2020)

IL-17A derived from mast cells contributes to tumor fibrosis in peritoneal dissemination of gastric cancer. Inhibiting degranulation of mast cells might be a promising treatment strategy to control organ fibrosis.

Keyphrases

liver fibrosis
signaling pathway
combination therapy
replacement therapy
smoking cessation