Induction of apoptosis via proteasome inhibition in leukemia/lymphoma cells by two potent piperidones.

Lisett ContrerasRuben I CalderonArmando Varela-RamirezHong-Yu ZhangYuan QuanUmashankar DasJonathan R DimmockRachid SkoutaRenato J Aguilera

Published in: Cellular oncology (Dordrecht) (2018)

Our data indicate that the cytotoxic activity of P1 and P2 on leukemia/lymphoma cells is mediated by proteasome inhibition, leading to activation of pro-apoptotic pathways.

Keyphrases

cell cycle arrest
induced apoptosis
cell death
endoplasmic reticulum stress
acute myeloid leukemia
bone marrow
anti inflammatory
pi k akt
signaling pathway
machine learning
electronic health record
cell proliferation
artificial intelligence