Mechanisms of Obesity-Induced Changes in Pharmacokinetics of IgG in Rats.

Xizhe GaoYi-Hua ShengSijia YuJiadong LiRaymond RosaSimone GirgisTiffany GuoLuigi BrunettiLeonid Kagan

Published in: Pharmaceutical research (2023)

We identified important obesity-induced changes in the pharmacokinetics of IgG. Results can potentially facilitate optimization of the dosing of IgG-based therapeutics in the obese population.

Keyphrases

weight loss
metabolic syndrome
insulin resistance
type diabetes
high fat diet induced
weight gain
adipose tissue
bariatric surgery
small molecule
skeletal muscle