The radiosensitizer Onalespib increases complete remission in 177Lu-DOTATATE-treated mice bearing neuroendocrine tumor xenografts.

Sara Lundsten Diana Spiegelberg Nakul Ravi Raval Marika Nestor

Published in: European journal of nuclear medicine and molecular imaging (2020)

Treatment with Onalespib potentiated 177Lu-DOTATATE therapy of NET xenografts with a favorable toxicity profile. Utilizing Onalespib's radiosensitizing properties with 177Lu-DOTATATE may lead to better therapeutic results in the future and may reduce unwanted side effects in dose-limiting organs.

Keyphrases

pet ct
neuroendocrine tumors
high fat diet induced
rheumatoid arthritis
adipose tissue
mesenchymal stem cells
skeletal muscle
bone marrow