Wang-Bi Tablet Ameliorates DMM-Induced Knee Osteoarthritis through Suppressing the Activation of p38-MAPK and NF-κB Signaling Pathways in Mice.
Hui LiYan YouBing JiangHaidong LiXiang LiWei WuHong CaoXiaoyan ShenJun ZouPublished in: Evidence-based complementary and alternative medicine : eCAM (2021)
WBT can effectively inhibit articular cartilage injury and inflammatory response in KOA mice. The protective role of WBT in mice KOA was a result of the downregulation of NF-κB and p38-MAPK signal pathways.
Keyphrases
- signaling pathway
- knee osteoarthritis
- inflammatory response
- high fat diet induced
- lps induced
- pi k akt
- epithelial mesenchymal transition
- oxidative stress
- cell proliferation
- induced apoptosis
- nuclear factor
- metabolic syndrome
- mouse model
- toll like receptor
- immune response
- wild type
- adipose tissue
- drug induced
- endothelial cells