The RIVET RCT: Rifamycin SV MMX improves muscle mass, physical function, and ammonia in cirrhosis and minimal encephalopathy.
Jasmohan Singh BajajAndrew FaganEdith A GavisTravis MouselMary L GallagherPuneet PuriMichael FuchsBrian C DavisPhillip B HylemonHuiping ZhouVishwadeep AhluwaliaRobert CadrainMasoumeh SikaroodiPatrick M GillevetPublished in: Hepatology communications (2024)
RiVM is well tolerated in patients with MHE with changes in stool microbial composition and function, ammonia, inflammation, brain oxidative stress, and sarcopenia-related parameters without improvement in cognition. RiVM modulates the gut-brain axis and gut-muscle axis in cirrhosis.
Keyphrases
- oxidative stress
- white matter
- resting state
- skeletal muscle
- functional connectivity
- anaerobic digestion
- room temperature
- microbial community
- dna damage
- cerebral ischemia
- ischemia reperfusion injury
- multiple sclerosis
- diabetic rats
- induced apoptosis
- endoplasmic reticulum stress
- blood brain barrier
- community dwelling