Genetic Correlates of Treatment-Resistant Depression: Insights from Polygenic Scores Across Cognitive, Temperamental, and Sleep Traits in the All of US cohort.

The findings underscore the importance of considering predisposing factors when managing and treating TRD. They suggest potential intervening pathways through tailored approach with the identified predisposing characteristics, reducing the risk of progression to treatment resistance in depression. Personalized genetic information that measures the underlying predispositions could eventually enhance therapeutic strategies.