Lipopolysaccharide decreases cochlear blood flow dose dependently in a guinea pig animal model via TNF signaling.

Friedrich IhlerSaskia FreytagBenedikt KloosJennifer Lee SpiegelFrank HaubnerMartin CanisBernhard G WeissMattis Bertlich

Published in: Microcirculation (New York, N.Y. : 1994) (2021)

Lipopolysaccharide shows a dose-dependent effect on cochlear microcirculation; this effect can already be observed after 30 min. Pretreatment with etanercept can abrogate this effect, indicating that TNF mediates the effect of LPS on cochlear microcirculation.

Keyphrases

blood flow
rheumatoid arthritis
inflammatory response
toll like receptor
hearing loss
lps induced
anti inflammatory