Isolated downregulation of HCN2 in ventricles of rats with streptozotocin-induced diabetic cardiomyopathy.

Katarina HadovaEva KralovaGabriel DokaLenka Bies PivackovaZuzana KmecovaPeter KrenekJan Klimas

Published in: BMC cardiovascular disorders (2021)

This result together with downregulated HCN2 channels suggest that HCN channels might be an integral part of ventricular electric remodelling and might play a role in cardiac repolarization projected in altered arrhythmogenic profile of diabetic heart.

Keyphrases

diabetic rats
heart failure
left ventricular
type diabetes
wound healing
oxidative stress
high fat diet
high glucose
climate change
cell proliferation
signaling pathway
atrial fibrillation
diabetic nephropathy
metabolic syndrome