Three patients highlighting potential pitfalls in platelet refractory testing.

Michel AttiehEdward A DentLogan HappneyJohn D RobackDavid N AlterEileen BarretteCaroline ThenHarold Clifford Sullivan

Published in: Transfusion (2023)

These cases highlight the importance of investigating incongruent results. Cases #1 and #2 demonstrate PXM pitfalls: ABO incompatibility can result in positive PXM and false-negative PXM can occur in the setting of the prozone effect. Case #3 reveals the importance of knowing a test's sensitivity. Centers that only perform ind-PAS may fail to detect HLA antibodies.

Keyphrases

end stage renal disease
newly diagnosed
ejection fraction
chronic kidney disease
peritoneal dialysis
risk assessment
patient reported outcomes
climate change