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The antiviral drug tenofovir, an inhibitor of Pannexin-1-mediated ATP release, prevents liver and skin fibrosis by downregulating adenosine levels in the liver and skin.

Jessica L FeigAranzazu MedieroCarmen CorciuloHailing LiuJin ZhangMiguel Perez-AsoLaura PicardTuere WilderBruce N Cronstein
Published in: PloS one (2017)
These studies suggest that tenofovir, a widely used antiviral agent, could be useful in the treatment of fibrosing diseases.
Keyphrases
  • soft tissue
  • wound healing
  • antiretroviral therapy
  • interstitial lung disease
  • mouse model
  • systemic sclerosis
  • combination therapy
  • replacement therapy
  • case control
  • adverse drug