PKM2 rewires glucose metabolism during radiation therapy to promote an antioxidant response and glioblastoma radioresistance.
Justine BailleulYangjingyi RuanLobna AbdulrahmanAndrew J ScottTaha YazalDavid SungKeunseok ParkHanna HoangJuan NathanielFang-I ChuDaisy PalomeraAnahita SehgalJonathan E TsangDavid A NathansonShili XuJunyoung O ParkJohanna Ten HoeveKruttika BhatNathan QiHarley I KornblumDorthe SchaueWilliam H McBrideCostas A LyssiotisDaniel R WahlErina VlashiPublished in: Neuro-oncology (2023)
These findings open the possibility that interventions designed to target cancer-specific regulators of metabolic plasticity, such as PKM2, rather than specific metabolic pathways, have the potential to improve the radiotherapeutic outcomes in GBM patients.
Keyphrases
- radiation therapy
- end stage renal disease
- newly diagnosed
- ejection fraction
- physical activity
- chronic kidney disease
- prognostic factors
- skeletal muscle
- adipose tissue
- insulin resistance
- dna damage
- dna damage response
- climate change
- anti inflammatory
- metabolic syndrome
- young adults
- radiation induced
- dna repair
- cancer stem cells