Phototriggered labeling and crosslinking by 2-nitrobenzyl alcohol derivatives with amine selectivity.

Chenxi WangYuan LiuChunyan BaoYuan XueYaowu ZhouDasheng ZhangQiuning LinLinyong Zhu

Published in: Chemical communications (Cambridge, England) (2020)

Here we report the use of 2-nitrobenzyl alcohol (NB) as a photoreactive group with amine selectivity and explore its applications for photoaffinity labeling and crosslinking of biomolecules. This work confirms that NB is an efficient photoreactive group and has great potential in drug discovery, chemical biology and protein engineering.

Keyphrases

drug discovery
alcohol consumption
protein protein
amino acid
structure activity relationship