T cell infiltration on local CpG-B delivery in early-stage melanoma is predominantly related to CLEC9A+CD141+ cDC1 and CD14+ antigen-presenting cell recruitment.
Bas D KosterMarta López GonzálezMari Fcm van den HoutAnnelies W TurksmaBerbel Jr SluijterBarbara G MolenkampPaul Am van LeeuwenSaskia VosslamberRik J ScheperAlfons Jm van den EertweghM Petrousjka van den TolEkaterina J JordanovaTanja D de GruijlPublished in: Journal for immunotherapy of cancer (2021)
The CpG-B-induced concerted recruitment of cDC1 and CD14+ APC to the injection site and its draining lymph nodes may allow for both the (cross-)priming of T cells and their subsequent homing to effector sites.