The Influence of Long Carbon Chains on the Antioxidant and Anticancer Properties of N -Substituted Benzisoselenazolones and Corresponding Diselenides.

Organoselenium compounds are well-known for their numerous biocapacities, which result from the uniqueness of the selenium atom and the possibility of constructing heterorganic molecules that can mimic the activity of selenoenzymes, crucial for a multitude of important physiological processes. In this paper, we have synthesized a series of N -substituted benzisoselenazolones and corresponding diphenyl diselenides possessing lipophilic long carbon chains, solely or with additional polar insets: phenyl linkers and ester groups. Evaluation of their antioxidant and cytotoxic activity revealed an increased H 2 O 2 -reduction potential of diphenyl diselenides bearing N -octyl, ethyl N -(12-dodecanoate)- and N -(8-octanoate) groups, elevated radical scavenging activity of 2,2'-diselenobis( N -dodecylbenzamide) and a promising cytotoxic potential of N -(4-dodecyl)phenylbenzisoselenazol-3(2 H )-one.