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Impact of treatment schedule on the efficacy of cytostatic and immunostimulatory agents.

Giulia PetroniLorenzo Galluzzi
Published in: Oncoimmunology (2021)
Radiation therapy (RT) and cyclin-dependent kinase 4/6 (CDK4/6) inhibitors mediate poorly overlapping cytostatic and immunostimulatory effects, suggesting that combinatorial regimens may enable supra-additive tumor control. Our preclinical findings demonstrate that administration schedule stands out as a major determinant of efficacy when RT and CDK4/6 inhibitors are combined for breast cancer therapy.
Keyphrases
  • cell cycle
  • cancer therapy
  • radiation therapy
  • cell proliferation
  • protein kinase
  • tyrosine kinase
  • bone marrow
  • cell cycle arrest