Nicotinamide N-methyltransferase inhibits autophagy induced by oxidative stress through suppressing the AMPK pathway in breast cancer cells.

Haitao YuXi ZhouYanzhong WangXucheng HuangJun YangJin ZengGuoli LiXinyou XieJun Zhang

Published in: Cancer cell international (2020)

We conclude that NNMT inhibits the autophagy induced by oxidative stress through the ROS-mediated AMPK-ULK1 pathway in breast cancer cells and may protect breast cancer cells against oxidative stress through autophagy suppression.

Keyphrases

oxidative stress
breast cancer cells
dna damage
cell death
induced apoptosis
diabetic rats
signaling pathway
ischemia reperfusion injury
endoplasmic reticulum stress
skeletal muscle
protein kinase
reactive oxygen species