The Association between Non-Alcoholic Fatty Liver Disease (NAFLD) and Advanced Fibrosis with Serological Vitamin B12 Markers: Results from the NHANES 1999-2004.

Li LiQi HuangLinjian YangRui ZhangLeili GaoXueyao HanLinong JiXiantong Zou

Published in: Nutrients (2022)

Among vitamin B12-associated biomarkers, RBC folate was independently associated with elevated NAFLD risk, whereas MMA and HCY were associated with increased risk for advanced fibrosis in the total population and NAFLD participants. Our study highlighted the clinical diagnostic value of vitamin B12 metabolites and the possibility that vitamin B12 metabolism could be a therapeutic target for NASH. Further studies using recent perspective data with biopsy proven NASH could be conducted to validate our results.

Keyphrases

liver fibrosis
ms ms
ultrasound guided
big data
machine learning
case control
artificial intelligence
data analysis