Childhood Langerhans cell histiocytosis with severe lung involvement: a nationwide cohort study.

Solenne Le LouetMohamed-Aziz BarkaouiJean MironClaire GalambrunNathalie AladjidiPascal ChastagnerKamila KebailiCorinne Armari-AllaAnne LambilliotteJulien LejeuneDespina MoshousValeria Della ValleChiara SileoHubert Ducou Le PointeJean-François ChateilSylvain RenolleauJean-Eudes PiloquetAurelie PortefaixRalph EpaudRaphaël ChironEmmanuelle BugnetGwenaël LorillonAbdelatif TaziJean-François EmileJean DonadieuSébastien Héritier

Published in: Orphanet journal of rare diseases (2020)

Severe lung involvement is unusual in childhood LCH, but it is associated with high mortality. Treatment guidelines should be improved for this group of patients: viral infection prophylaxis and early administration of a new LCH therapy, such as targeted therapy.

Keyphrases

end stage renal disease
newly diagnosed
ejection fraction
early onset
chronic kidney disease
cell therapy
single cell
prognostic factors
peritoneal dialysis
childhood cancer