Cobalt-Catalyzed α-Arylation of Substituted α-Halogeno β-Lactams.
Vanessa KochMélanie M LorionEtienne BardeStefan BräseJanine CossyPublished in: Organic letters (2019)
The treatment of 3-bromo β-lactams by an aryl Grignard, in the presence of CoCl2 (2 mol %) and TMEDA (2 mol %) in THF, produces 3-aryl β-lactams in good yields and excellent diastereoselectivity.