A randomized, double-blind trial comparing the effect of two blood pressure targets on global brain metabolism after out-of-hospital cardiac arrest.
Simon MølstrømTroels Halfeld NielsenCarl-Henrik NordstrømAxel ForsseSøren MøllerSøren VenøDmitry MamaevTomas TencerÁsta TheódórsdóttirThomas KrøigårdJacob MøllerChristian HassagerJesper KjærgaardHenrik SchmidtPalle ToftPublished in: Critical care (London, England) (2023)
Among comatose patients resuscitated from OHCA, targeting a higher MAP 180 min after ROSC did not significantly improve cerebral energy metabolism within 96 h of post-resuscitation care. Patients with a poor clinical outcome exhibited significantly worse biochemical patterns, probably illustrating that insufficient tissue oxygenation and recirculation during the initial hours after ROSC were essential factors determining neurological outcome.
Keyphrases
- cardiac arrest
- blood pressure
- end stage renal disease
- clinical trial
- newly diagnosed
- ejection fraction
- healthcare
- chronic kidney disease
- cardiopulmonary resuscitation
- phase iii
- study protocol
- cerebral ischemia
- phase ii
- palliative care
- prognostic factors
- peritoneal dialysis
- subarachnoid hemorrhage
- heart rate
- type diabetes
- quality improvement
- adipose tissue
- pain management
- blood brain barrier
- cancer therapy
- multiple sclerosis
- open label
- patient reported outcomes
- functional connectivity
- affordable care act