Host genetic susceptibility to Clostridium difficile infections in patients undergoing autologous stem cell transplantation: a genome-wide association study.

Senu ApewokinJeannette Y LeeJulia A GoodwinKent D McKelveyOwen W StephensDaohong ZhouElizabeth Ann Coleman

Published in: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer (2018)

Low serum albumin and genes RLBP1L1 and ASPH located on chromosome 8 and ATP7B on chromosome 13 were associated with CDI. Of particular interest is ATP7B given its copper modulatory role and the sporicidal properties of copper against Clostridium difficile.

Keyphrases

clostridium difficile
stem cell transplantation
genome wide association study
copy number
patients undergoing
genome wide
high dose
oxide nanoparticles
bone marrow
dna methylation
cell therapy
platelet rich plasma
stem cells
mesenchymal stem cells
bioinformatics analysis
genome wide identification