An electrografted monolayer of polyaniline as a tuneable platform for a glucose biosensor.
Elžbieta RagauskaitėSamuelis MarčiukaitisIngrida RadveikienėGintautas BagdžiūnasPublished in: Nanoscale (2024)
Polyaniline (PANI), a nanostructured conducting polymer, has shown significant potential in optical and bioelectrochemical devices. However, its performance and stability on various substrates are hindered by weak adhesion to the surface. In this study, a strongly adherent polyaniline conducting polymer layer with a thickness of five nanometers was electrografted onto an initiating monolayer on gold and tin-doped indium oxide substrates. These electrografted monolayers consist of vertically oriented fully oxidized-protonated (pernigraniline salt) and deprotonated (pernigraniline base) forms of polyaniline. The monolayer exhibits pH-dependent colour changes and it is suitable for enzyme compatibility. In light of these findings, we have developed and characterized an electrochemical glucose biosensor based on the monolayer of polyaniline on a gold electrode. The biosensor utilizes glucose oxidase as the biorecognition element for the selective detection of glucose concentrations in real blood plasma samples.
Keyphrases
- carbon nanotubes
- reduced graphene oxide
- gold nanoparticles
- label free
- quantum dots
- solid phase extraction
- blood glucose
- sensitive detection
- type diabetes
- high resolution
- metabolic syndrome
- molecularly imprinted
- optical coherence tomography
- cystic fibrosis
- ionic liquid
- adipose tissue
- high speed
- human health
- silver nanoparticles
- biofilm formation
- insulin resistance
- staphylococcus aureus
- simultaneous determination
- highly efficient
- loop mediated isothermal amplification