Therapeutic effects of adipose-tissue-derived mesenchymal stromal cells and their extracellular vesicles in experimental silicosis.

Elga BandeiraHelena OliveiraJohnatas D SilvaRubem F S Menna-BarretoChristina M TakyiaJung S SukKenneth W WitwerMichael E PaulaitisJustin HanesPatricia R M RoccoMarcelo Marcos Morales

Published in: Respiratory research (2018)

Both AD-MSCs and EVs, locally delivered, ameliorated fibrosis and inflammation, but dose-enhanced EVs yielded better therapeutic outcomes in this model of silicosis.

Keyphrases

adipose tissue
pulmonary fibrosis
oxidative stress
mesenchymal stem cells
bone marrow
insulin resistance
high fat diet
umbilical cord
type diabetes
metabolic syndrome
skeletal muscle
glycemic control
weight loss