Functional genomics of human clear cell sarcoma: genomic, transcriptomic and chemical biology landscape for clear cell sarcoma.

Samuel V RasmussenAgnieszka WozniakMelvin LatharaJoshua M GoldenbergBenjamin M SamudioLissett R BickfordKiyo NagamoriHollis WrightAndrew D WoodsShefali ChauhanChe-Jui LeeErin R RudzinskiMichael K SwiftTadashi KondoDavid E FisherEvgeny ImyanitovIsidro MachadoAntonio Llombart-BoschIrene L AndrulisNalan GokgozJay WunderHiroshi MirotakiTakuro NakamuraGanapati SrinivasaKhin ThwayRobin L JonesPaul H HuangNoah E BerlowPatrick SchöffskiCharles Keller

Published in: British journal of cancer (2023)

These studies of the genomic, transcriptomic and chemical biology landscape represent a resource 'atlas' for the field of CCS investigation and drug development. CHK inhibitors are identified as having potential relevance, CREB1 inhibitors non-dependence of CCS on CREB1 activity was established, and the potential utility of HER3 ADC being used in CCS is found.

Keyphrases

single cell
clear cell
rna seq
copy number
human health
magnetic resonance
dna methylation
risk assessment
oxidative stress
magnetic resonance imaging
climate change
genome wide