The effect of heat-killed Lactobacillus brevis SBL88 on improving selective hepatic insulin resistance in non-alcoholic fatty liver disease mice without altering the gut microbiota.

Hidemi HayashiKoji SawadaHiroki TanakaKazuki MuroTakumu HasebeShunsuke NakajimaToshikatsu OkumuraMikihiro Fujiya

Published in: Journal of gastroenterology and hepatology (2023)

SBL mice exhibited partially improved selective hepatic insulin resistance. Our data suggest that heat-killed L. brevis SBL88 could attenuate the clinical features of NAFLD that are not mediated by alterations in the gut microbiota.

Keyphrases

high fat diet induced
insulin resistance
heat stress
adipose tissue
metabolic syndrome
type diabetes
skeletal muscle
high fat diet
electronic health record
wild type
weight loss