Proenkephalin A as a marker for glomerular filtration rate in critically ill children: validation against gold standard iohexol GFR measurements.
Nori J L SmeetsOliver HartmannJanin SchulteMichiel F SchreuderSaskia N de WildtPublished in: Clinical chemistry and laboratory medicine (2022)
The correlation of PENK with mGFR was as good as SCr-based eGFR-mGFR correlation. To determine the added value of PENK in paediatric clinical care and prior to implementation, PENK reference values are needed and the development and validation of a paediatric PENK-based eGFR equation is necessary.