miRNA-218-5p increases cell sensitivity by inhibiting PRKDC activity in radiation-resistant lung carcinoma cells.
Xiaoke ChenYuanyuan XuLong JiangQiang TanPublished in: Thoracic cancer (2021)
miRNA-218-5p could induce apoptosis and enhance the radiosensitivity of LC cells through regulatory activities, thus suggesting its application as a potential target for LC treatment.
Keyphrases
- cell cycle arrest
- induced apoptosis
- cell death
- endoplasmic reticulum stress
- simultaneous determination
- oxidative stress
- single cell
- signaling pathway
- cell therapy
- mass spectrometry
- transcription factor
- liquid chromatography
- solid phase extraction
- human health
- radiation therapy
- mesenchymal stem cells
- radiation induced
- combination therapy
- tandem mass spectrometry
- climate change
- high resolution mass spectrometry