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Catalytic Nanoassemblies Formed by Short Peptides Promote Highly Enantioselective Transfer Hydrogenation.

Martin A DolanPrem N BasaOleksii ZozuliaZsófia LengyelRené LeblEric M KohnSagar BhattacharyaIvan V Korendovych
Published in: ACS nano (2019)
Self-assembly enables formation of incredibly diverse supramolecular structures with practically important functions from simple and inexpensive building blocks. Here, we show how a semirational, bottom-up approach to create emerging properties can be extended to a design of highly enantioselective catalytic nanoassemblies. The designed peptides comprising as few as two amino acid residues spontaneously self-assemble in the presence of metal ions to form supramolecular, vesicle-like nanoassemblies that promote transfer hydrogenation of ketones in an aqueous phase with excellent conversion rates and enantioselectivities (>90% ee).
Keyphrases
  • amino acid
  • water soluble
  • energy transfer
  • quantum dots
  • crystal structure
  • high resolution
  • aqueous solution