Mixed-Ligand Metal-Organic Frameworks for All-in-One Theranostics with Controlled Drug Delivery and Enhanced Photodynamic Therapy.
Hui ZhangXue-Bo YinPublished in: ACS applied materials & interfaces (2022)
Mixed-ligand metal-organic frameworks (MOFs) multiply the properties and improve the versatility of conventional MOFs for theranostic applications. A tumor targeting and tumoral microenvironment-responsive system is significant for specific and efficient cancer theranostics. Herein, we report a kind of versatile mixed-porphyrin ligand MOF as a multifunctional matrix for multimodality-imaging-guided synergistic therapy. Tetrakis(4-carboxyphenyl)porphyrin (TCPP) shows the properties of fluorescence (FL) and photodynamic therapy (PDT), while Mn-TCPP owns magically the properties of T 1 -weighted magnetic resonance (MR) imaging and photothermal conversion for photothermal imaging and photothermal therapy (PTT). Because of the same coordination capacity and mode of TCPP and Mn-TCPP to Zr 4+ ions, MOFs with adjustable ligand ratios were easily prepared. The mixed-ligand MOFs exhibited a high drug loading capacity for 10-hydroxycamptothecin (HCPT, 65%). After modification with hyaluronic acid (HA) through a disulfide bond (-S-S-), the MOF-S-S-HA composites possess enhanced PDT and tumor-targeted redox-responsive drug release properties due to the -S-S- bond. Thus, excellent fluorescence, MR, and photothermal trimodality imaging, redox-responsive drug release, and enhanced PDT/PTT are integrated together in the mixed-ligand MOFs as "all-in-one" theranostic agents.
Keyphrases
- metal organic framework
- photodynamic therapy
- cancer therapy
- drug release
- drug delivery
- fluorescence imaging
- magnetic resonance
- high resolution
- hyaluronic acid
- contrast enhanced
- stem cells
- squamous cell carcinoma
- single molecule
- computed tomography
- magnetic resonance imaging
- bone marrow
- electron transfer
- young adults
- network analysis
- mass spectrometry
- drug induced
- childhood cancer
- gold nanoparticles
- reduced graphene oxide