The chromogranin A1-373 fragment reveals how a single change in the protein sequence exerts strong cardioregulatory effects by engaging neuropilin-1.

Carmine Rocca Fedora Grande Maria Concetta Granieri Barbara Colombo Anna De Bartolo Francesca Giordano Vittoria Rago Nicola Amodio Bruno Tota Maria Carmela Cerra Bruno Rizzuti Angelo Corti Domenico Gabriele Teresa Pasqua

Published in: Acta physiologica (Oxford, England) (2020)

These results suggest that CgA1-373 is a new cardioregulatory hormone and that the removal of R373 represents a critical switch for turning "off" its cardioregulatory activity.

Keyphrases

amino acid
protein protein
binding protein
small molecule