Systematic risk analysis of radiation pneumonitis in breast cancer: role of cotreatment with chemo-, endocrine, and targeted therapy.
Julian MangesiusDanijela MinaschKatharina FinkMeinhard Nevinny-StickelPeter LukasUte GanswindtThomas SeppiPublished in: Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] (2022)
Common treatment schedules in sequential chemoradiation following breast-conserving surgery only moderately increase lung toxicity, mainly as an asymptomatic complication, or to a minor extent, as transient pneumonitis ≤ grade 2. However, combined treatment with tamoxifen and the LHRH analog goserelin significantly increased the risk of pneumonitis in breast cancer patients after chemoradiation. Thus, closer surveillance of involved patients is advisable.
Keyphrases
- locally advanced
- minimally invasive
- rectal cancer
- newly diagnosed
- interstitial lung disease
- ejection fraction
- public health
- squamous cell carcinoma
- prognostic factors
- radiation therapy
- neoadjuvant chemotherapy
- coronary artery disease
- acute coronary syndrome
- rheumatoid arthritis
- breast cancer cells
- blood brain barrier
- estrogen receptor
- idiopathic pulmonary fibrosis
- percutaneous coronary intervention
- subarachnoid hemorrhage