Prediction for oxaliplatin-induced liver injury using patient-derived liver organoids.
Kumiko TatsumiHiroshi WadaShinichiro HasegawaKei AsukaiShigenori NagataTomoya EkawaTakashi AkazawaYu MizoteShintaro OkumuraRyosuke OkamuraMasayuki OhueKazutaka ObamaHideaki TaharaPublished in: Cancer medicine (2024)
These results suggested that L-OHP-induced liver injury may be caused by mitochondrial oxidative damage. Furthermore, patient-derived liver organoids may be used to assess susceptibility to L-OHP-induced liver injury in individual patients.