Bile acid metabolites predict multiple sclerosis progression and supplementation is safe in progressive disease.
Dimitrios Christos LadakisKimystian L HarrisonMatthew D SmithKrista SolemSachin P GadaniLarissa JankSoonmyung HwangFarzaneh FarhadiBlake E DeweyKathryn C FitzgeraldElias S SotirchosShiv SaidhaPeter A CalabresiPavan BhargavaPublished in: medRxiv : the preprint server for health sciences (2024)
Bile acid metabolism in MS is linked with brain and retinal atrophy. TUDCA supplementation in PMS is safe, tolerable and has measurable biological effects that warrant further evaluation in larger trials with a longer treatment duration.