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Molecular surveillance for operationally relevant genetic polymorphisms in Plasmodium falciparum in Southern Chad, 2016-2017.

Sukanta DasClément Kérah-HinzoumbéMoundiné KebfénéSuttipat SrisuthamTog-Yeum NagorngarNaowarat SaralambaRanitha VongpromekTeeradet KhomvarnCarol H SibleyPhilippe J GuérinMallika ImwongMehul Dhorda
Published in: Malaria journal (2022)
These results provide information on the likely high efficacy of artemisinin-based combinations commonly used in Chad, but suggest decreasing levels of sensitivity to lumefantrine and high levels of resistance to sulfadoxine-pyrimethamine used for seasonal malaria chemoprevention and intermittent preventive therapy in pregnancy. A majority of parasites had mutations in the pfk13 gene, none of which are known to be associated with artemisinin resistance. A therapeutic efficacy study needs to be conducted to confirm the efficacy of artemether-lumefantrine.
Keyphrases
  • plasmodium falciparum
  • public health
  • genome wide
  • copy number
  • high intensity
  • stem cells
  • single molecule
  • mesenchymal stem cells
  • bone marrow