FKN secreted by kidney epithelial cells regulates macrophage activation in lupus nephritis via the Hippo signaling pathway.

Yao Zuo Xiuhong Pan Xiaochao Wang Yan-Wu You

Published in: Lupus (2023)

FKN down-regulation reduced the activation of macrophages in renal tissue and alleviated kidney damage by activating HSP. The regulatory effect of FKN on HSP should be confirmed in patients with LN, and the mechanism of FKN in LN should be further explored.

Keyphrases

signaling pathway
heat shock protein
heat shock
heat stress
pi k akt
oxidative stress
adipose tissue
epithelial mesenchymal transition
transcription factor
induced apoptosis
endoplasmic reticulum stress