Continuous Levodopa Delivery with an Intraoral Micropump System: An Open-Label Pharmacokinetics and Clinical Study.

C Warren OlanowDeborah McIntyreMichele MatarazzoMika LeinonenAndrew McGarryCornelia KampJulie KennedyMargherita TortiRejko KrugerJosé A ObesoFabrizio StocchiEphraim HellerKarl Kieburtz

Published in: Movement disorders : official journal of the Movement Disorder Society (2024)

Continuous delivery of LD/CD using the DopaFuse system was associated with significantly less variability in plasma levodopa concentrations and reductions in OFF time compared to treatment with standard oral LD/CD therapy and was well tolerated. © 2024 International Parkinson and Movement Disorder Society.

Keyphrases

parkinson disease
deep brain stimulation
nk cells
clinical trial
stem cells
combination therapy
bone marrow
mesenchymal stem cells
chemotherapy induced