Cobalt Single-Atom Nanozyme Co-Administration with Ascorbic Acid Enables Redox Imbalance for Tumor Catalytic Ablation.
Guoyuan RenMingju LuZhiqiang ZhaoFengjuan QinKai LiWenxing ChenYu-Qing LinPublished in: ACS biomaterials science & engineering (2023)
The elevated antioxidant defense system in cancer cells can lead to resistance to treatments involving ROS. Breaking the redox balance of the cell system through a "open up the source and regulate the flow" strategy can inhibit the growth of cancer cells and thus design a cancer treatment strategy. Here, cobalt single atom-supported N-doped carbon nanozymes (Co SA-N/C) were synthesized via a simple sacrificial template method, which can mimic the properties of ascorbate oxidase and glutathione oxidase effectively. The synthesized Co SA-N/C can induce the generation of active oxygen by accelerating the oxidation of ascorbic acid (AA) and destroy the endogenous active oxygen scavenging system by consuming the main antioxidant, glutathione (GSH). In-depth in vitro and in vivo investigations indicate that compared with solo therapy, Co SA-N/C together with AA can significantly enhance the anti-tumor efficiency by simultaneously elevating oxidative stress and consuming the overexpressed glutathione (GSH) through the redox reaction catalyzed by Co SA-N/C. This work provides a promising route for developing nanozyme-guided and ascorbate-based antitumor agents.
Keyphrases
- electron transfer
- oxidative stress
- dna damage
- molecular dynamics
- metal organic framework
- anti inflammatory
- cell therapy
- quantum dots
- reduced graphene oxide
- cell death
- diabetic rats
- induced apoptosis
- optical coherence tomography
- stem cells
- highly efficient
- room temperature
- mass spectrometry
- signaling pathway
- oxide nanoparticles
- visible light
- endoplasmic reticulum stress
- catheter ablation
- crystal structure
- simultaneous determination