Mutational spectrum of TP53 gene correlates with nivolumab treatment efficacy in advanced gastric cancer (TP53MUT study).

Koji AndoYoshiaki NakamuraHiroyuki KitaoMototsugu ShimokawaDaisuke KotaniHideaki BandoTomohiro NishinaTakanobu YamadaSatoshi YukiYukiya NaritaHiroki HaraTakashi OhtaTaito EsakiYasuo HamamotoKen KatoYoshiyuki YamamotoKeiko MinashiKoushiro OhtsuboNaoki IzawaHiasto KawakamiTakeshi KatoTaroh SatohNaohiro OkanoAkihito TsujiKentaro YamazakiTakayuki YoshinoYoshihiko MaeharaEiji Oki

Published in: British journal of cancer (2023)

Nivolumab showed better efficacy in TP53 wt patients than in mutant patients. Among TP53 mutant patients, the frameshift type may have efficacy from nivolumab treatment.

Keyphrases

end stage renal disease
ejection fraction
chronic kidney disease
newly diagnosed
prognostic factors
peritoneal dialysis
radiation therapy
patient reported outcomes
dna methylation
genome wide
lymph node
combination therapy
patient reported
rectal cancer
replacement therapy
smoking cessation
wild type