The 2019-2020 dengue fever epidemic: genomic markers indicating severity in Dominican Republic children.

Brittany N SimpsonMiguel E Mejía SangYonairy Collado PuelloElvira J Diaz BrockmansMaría F Díaz SotoStephanie M Rivera DefillóKarla M Taveras CruzJavier O Santiago PérezAmmar HusamiMelissa E DayValentina PilipenkoRafael MenaCesár MotaMargaret K HostetterLouis J MugliaElizabeth SchlaudeckerJavier Gonzalez Del ReyLisa J MartinCarlos E Prada

Published in: Journal of the Pediatric Infectious Diseases Society (2022)

We performed an observational cohort study to assess associations between genetic factors of dengue fever (DF) severity in children in the Dominican Republic. 488 participants had serologically confirmed DF. We replicated the association between IFIH1 gene (rs1990760) and severe DF (n=80/488, p=0.006) and identified novel associations needing further investigation.

Keyphrases

zika virus
copy number
young adults
dengue virus
genome wide
aedes aegypti
early onset
gene expression
transcription factor
genome wide identification