Increased Frequency of Clonal Hematopoiesis of Indeterminate Potential in Bloom Syndrome Probands and Carriers.
Isabella LinAngela WeiTsumugi A GeboPaul C BoutrosMaeve FlanaganNicole KucineChristopher M CunniffValerie A ArboledaVivian Y ChangPublished in: medRxiv : the preprint server for health sciences (2024)
could be sufficient to increase the risk of clonal hematopoiesis. These findings warrant further studies in larger cohorts to determine the significance of CHIP as a potential biomarker of aging, cancer, cardiovascular disease, morbidity and mortality.
Keyphrases
- cardiovascular disease
- papillary thyroid
- squamous cell
- high throughput
- type diabetes
- hematopoietic stem cell
- case report
- circulating tumor cells
- lymph node metastasis
- human health
- case control
- squamous cell carcinoma
- coronary artery disease
- risk assessment
- metabolic syndrome
- childhood cancer
- climate change
- single cell