[(18)F]FE@SNAP-a specific PET tracer for melanin-concentrating hormone receptor 1 imaging?

Cécile PhilippeDaniela HaeuslerThomas SchererClemens FürnsinnMarkus ZeilingerWolfgang WadsakKarem ShanabHelmut SpreitzerMarcus HackerMarkus Mitterhauser

Published in: EJNMMI research (2016)

Since [(18)F]FE@SNAP uptake was significantly blocked in the lateral hypothalamus, there is strong evidence that [(18)F]FE@SNAP is a highly suitable agent for specific MCHR1 imaging in the central nervous system. Additionally, this finding is supported by the specific blocking in the ventricular system, where the MCHR1 is expressed in the ependymal cells. These findings suggest that [(18)F]FE@SNAP could serve as a useful imaging and therapy monitoring tool for MCHR1-related pathologies.

Keyphrases

high resolution
metal organic framework
heart failure
induced apoptosis
computed tomography
positron emission tomography
stem cells
left ventricular
cell cycle arrest
pet ct
oxidative stress
fluorescence imaging
cell proliferation
atrial fibrillation
mesenchymal stem cells
photodynamic therapy
bone marrow
pi k akt