Wnt receptor gene FZD1 was associated with schizophrenia in genome-wide SNP analysis of the Australian Schizophrenia Research Bank cohort.

Xiaoman LiuSiew-Kee LowJoshua R AtkinsJing Qin WuWilliam R ReayHeath M CairnsMelissa J GreenUlrich SchallAssen JablenskyBryan MowryPatricia T MichieStan V CattsFrans HenskensChristos PantelisCarmel LoughlandAlan V BoddyPaul A TooneyRodney J ScottVaughan J CarrMurray J Cairns

Published in: The Australian and New Zealand journal of psychiatry (2019)

The identification of FZD1, as an independent association signal at the gene level, supports the hypothesis that the Wnt signalling pathway is altered in the pathogenesis of schizophrenia and may be an important target for therapeutic development.

Keyphrases

genome wide
bipolar disorder
dna methylation
copy number
stem cells
cell proliferation
binding protein
genetic diversity