Dexibuprofen ameliorates peripheral and central risk factors associated with Alzheimer's disease in metabolically stressed APPswe/PS1dE9 mice.
Miren EtchettoElena Sánchez-LopezAmanda CanoMarina CarrascoKatherine HerreraPatricia R ManzineTriana Espinosa-JimenezOriol BusquetsEster VerdaguerJordi OlloquequiCarme AuladellJaume FolchAntoni CaminsPublished in: Cell & bioscience (2021)
Collectively, evidence suggest that chronic administration of DXI prevents the progression of AD through the regulation of inflammation which contribute to improve hallmarks of this pathology. Thus, this compound could constitute a novel therapeutic approach in the treatment of AD in a combined therapy.