Epigenetics: the first 25 centuries.

Published in: Philosophical transactions of the Royal Society of London. Series B, Biological sciences (2019)

Epigenetics is a natural progression of genetics as it aims to understand how genes and other heritable elements are regulated in eukaryotic organisms. The history of epigenetics is briefly reviewed, together with the key issues in the field today. This themed issue brings together a diverse collection of interdisciplinary reviews and research articles that showcase the tremendous recent advances in epigenetic chemical biology and translational research into epigenetic drug discovery.This article is part of a discussion meeting issue 'Frontiers in epigenetic chemical biology'.

Keyphrases

drug discovery
dna methylation
gene expression
genome wide
transcription factor
genome wide identification