The effect of red blood cell transfusion on iron metabolism in critically ill patients.

Margit BoshuizenMaike E van HezelLisa van ManenMarleen StraatYvemarie B O SomsenAngelique M E Spoelstra-de ManNeil BlumbergRobin van BruggenNicole P Juffermans

Published in: Transfusion (2018)

Transfusion of a RBC unit transiently increases serum iron levels in intensive care unit patients. The increase in hepcidin levels after transfusion can further decrease iron release from intracellular storage making it available for erythropoiesis. RBC transfusion is associated with a decrease in haptoglobin levels in septic compared to nonseptic patients, but did not affect other markers of hemolysis.

Keyphrases

red blood cell
end stage renal disease
intensive care unit
cardiac surgery
newly diagnosed
ejection fraction
chronic kidney disease
prognostic factors
acute kidney injury
sickle cell disease
patient reported outcomes
iron deficiency
mechanical ventilation
acute respiratory distress syndrome