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Data-driven multiscale modeling reveals the role of metabolic coupling for the spatio-temporal growth dynamics of yeast colonies.

Jukka IntosalmiAdrian C ScottMichelle HaysNicholas FlannOlli Yli-HarjaHarri LähdesmäkiAimée M DudleyAlexander Skupin
Published in: BMC molecular and cell biology (2019)
We introduce a novel model for yeast colony formation, present a statistical methodology for model calibration in a data-driven manner, and demonstrate how the established model can be used to generate predictions across scales by validation against independent measurements of genetically distinct yeast strains.
Keyphrases
  • saccharomyces cerevisiae
  • escherichia coli
  • cell wall