Data-driven multiscale modeling reveals the role of metabolic coupling for the spatio-temporal growth dynamics of yeast colonies.
Jukka IntosalmiAdrian C ScottMichelle HaysNicholas FlannOlli Yli-HarjaHarri LähdesmäkiAimée M DudleyAlexander SkupinPublished in: BMC molecular and cell biology (2019)
We introduce a novel model for yeast colony formation, present a statistical methodology for model calibration in a data-driven manner, and demonstrate how the established model can be used to generate predictions across scales by validation against independent measurements of genetically distinct yeast strains.