Aortic aneurysms: current pathogenesis and therapeutic targets.
Min Ji ChoMi-Ran LeeJong-Gil ParkPublished in: Experimental & molecular medicine (2023)
Aortic aneurysm is a chronic disease characterized by localized expansion of the aorta, including the ascending aorta, arch, descending aorta, and abdominal aorta. Although aortic aneurysms are generally asymptomatic, they can threaten human health by sudden death due to aortic rupture. Aortic aneurysms are estimated to lead to 150,000 ~ 200,000 deaths per year worldwide. Currently, there are no effective drugs to prevent the growth or rupture of aortic aneurysms; surgical repair or endovascular repair is the only option for treating this condition. The pathogenic mechanisms and therapeutic targets for aortic aneurysms have been examined over the past decade; however, there are unknown pathogenic mechanisms involved in cellular heterogeneity and plasticity, the complexity of the transforming growth factor-β signaling pathway, inflammation, cell death, intramural neovascularization, and intercellular communication. This review summarizes the latest research findings and current pathogenic mechanisms of aortic aneurysms, which may enhance our understanding of aortic aneurysms.
Keyphrases
- aortic valve
- aortic dissection
- pulmonary artery
- left ventricular
- coronary artery
- pulmonary hypertension
- cell death
- transforming growth factor
- human health
- pulmonary arterial hypertension
- signaling pathway
- risk assessment
- epithelial mesenchymal transition
- heart failure
- oxidative stress
- vascular endothelial growth factor
- atrial fibrillation
- single cell
- optical coherence tomography