Functionalized GO Nanovehicles with Nitric Oxide Release and Photothermal Activity-Based Hydrogels for Bacteria-Infected Wound Healing.
Shaoshan HuangHuiling LiuKedan LiaoQinqin HuRui GuoKaixian DengPublished in: ACS applied materials & interfaces (2020)
Bacteria-infected wounds are attracting increasing attention, as antibiotic misuse and multidrug-resistant bacteria complicate their treatment. Herein, we reported a photothermal activity-based drug consisting of β-cyclodextrin (βCD)-functionalized graphene oxide (GO) near-infrared light-responsive nanovehicles combined with the nitric oxide donor BNN6, in a methacrylate-modified gelatin (GelMA)/hyaluronic acid graft dopamine (HA-DA) hydrogel. The synergistic effects of photothermal and gas therapies are expected to improve antibacterial efficiency and reduce drug resistance. The results revealed that GelMA/HA-DA/GO-βCD-BNN6 was an ideal antibacterial material that improved collagen deposition and angiogenesis and promoted wound healing in a mouse model of full-thickness skin repair, compared to the commercially available Aquacel Ag dressing. We developed a multifunctional nanocomposite hydrogel that exhibited antibacterial and angiogenic properties, adhesiveness, and mechanical properties that enhance the regeneration of bacteria-infected wounds.
Keyphrases
- wound healing
- cancer therapy
- hyaluronic acid
- nitric oxide
- drug delivery
- quantum dots
- photodynamic therapy
- multidrug resistant
- mouse model
- drug release
- hydrogen peroxide
- nitric oxide synthase
- stem cells
- chronic pain
- emergency department
- uric acid
- gold nanoparticles
- silver nanoparticles
- combination therapy
- room temperature
- cystic fibrosis
- single cell
- reduced graphene oxide
- visible light
- soft tissue
- tandem mass spectrometry
- essential oil
- smoking cessation
- solid phase extraction