Molybdenum Nanodots for Acute Lung Injury Therapy.
Jiayang YanZhongmin TangYanan LiHan WangJessica C HsuMengmeng ShiZi FuXiuru JiWeibo CaiDalong NiJieming QuPublished in: ACS nano (2023)
Acute respiratory disease syndrome (ARDS) is a common critical disease with high morbidity and mortality rates, yet specific and effective treatments for it are currently lacking. ARDS was especially apparent and rampant during the COVID-19 pandemic. Excess reactive oxygen species (ROS) production and an uncontrolled inflammatory response play a critical role in the disease progression of ARDS. Herein, we developed molybdenum nanodots (MNDs) as a functional nanomaterial with ultrasmall size, good biocompatibility, and excellent ROS scavenging ability for the treatment of acute lung injury (ALI). MNDs, which were administered intratracheally, significantly ameliorated lung oxidative stress, inflammatory response, protein permeability, and histological severity in ALI mice without inducing any safety issues. Importantly, transcriptomics analysis indicated that MNDs protected lung tissues by inhibiting the activation of the Nod-like receptor protein 3 (NLRP3)-dependent pyroptotic pathway. This work presents a promising therapeutic agent for patients suffering from ARDS.
Keyphrases
- inflammatory response
- lipopolysaccharide induced
- acute respiratory distress syndrome
- reactive oxygen species
- lps induced
- extracorporeal membrane oxygenation
- mechanical ventilation
- oxidative stress
- dna damage
- end stage renal disease
- respiratory failure
- cell death
- toll like receptor
- ejection fraction
- chronic kidney disease
- liver failure
- gene expression
- newly diagnosed
- binding protein
- single cell
- amino acid
- prognostic factors
- peritoneal dialysis
- type diabetes
- signaling pathway
- patient reported outcomes
- magnetic resonance imaging
- computed tomography
- diabetic rats
- magnetic resonance
- endothelial cells
- nlrp inflammasome
- drug induced
- ischemia reperfusion injury
- adipose tissue
- diffusion weighted imaging
- skeletal muscle
- immune response
- combination therapy